We have conducted an extensive number of projects in reproductive and developmental toxicology with pharmaceutical, veterinary pharmaceutical, chemical, agrochemical, food and consumer products. Together with comprehensive historical control databases, this extended experience allows our staff to conduct studies of standard up to very specific adapted designs.

Studies
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• Type

• Fertility (ICH segment I)
• Embryo-fetal development (ICH segment II)
• Pre and postnatal (ICH segment III)
• Multigeneration
• Juvenile
• Studies on sexually mature non-rodents with parameters of male or female reproductive functions (treatment at a specific time of the cycle possible).
• Uterotrophic assays (juvenile or castrated)
• Hershberger assays

• Oral: gavage, dietary admixtures, drinking water
• Parenteral:
  - Intravenous : bolus, slow injection, continuous infusion,
  - Other routes : subcutaneous, intradermal, intramuscular, intraperitoneal
• Dermal
• Other routes: please consult

• Neurobehavioral testing:
  - FOB
  - Learning and memory: our state-of-the-art facilities and equipment include multiple T maze : 3T or 9T (Cincinnati water maze) and Moris water maze (circular pool of water, no T)
• Sperm analysis (rodent and non-rodents): including motility, morphology and concentration
• Histopathology:
  - Male reproductive organs including testicular staging
  - Female reproductive organs including estrous cycle staging
• Toxicokinetics, pharmacokinetics: parental blood samples, fetal tissues, fetal blood, amniotic fluid, milk.
• Evaluation of effects on the skeleton: large range of investigational parameters possible, X-ray, DXA, pQCT, microCT, clinical chemistry, histomorphometry
• Genomics: very extended number of tissues can be collected and analyzed (PCR, Affymetrix micro-chips)

• Dedicated customized unit for the preparation of dosage forms
• Analytical chemistry for dosage forms analysis (results obtained prior to the administration)
• Statistical analysis