CIT's short term, tolerance and in-vitro toxicology department offers complete services in order to fulfil regulatory requirement or obtain screening data. Studies are designed according to international guidelines, including OECD, EC, OPPTS, ICH or Japanese guidelines.
| In-vivo tests |
Acute toxicity |
Fixed dose, "up-and-down", limit test or ICH guideline |
| Skin & eye irritation |
Single or repeated exposure |
| Sensitization studies |
Local Lymph Node Assay (LLNA)
Magnusson and Kligman test and Buehler test |
| Phototoxicity and photosensitization |
Guinea pig |
Local tolerance |
After single or repeated administrations by various routes including dermal, ocular, parenteral, nasal, vaginal, jugal pouch, etc. |
| In-vitro tests |
Hen chorioallantoic membrane
Bovine cornea opacity & permeability |
HETCAM
BCOP |
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Short term, tolerance and in-vitro toxicology