Biomarker discovery Generation of toxicity signature databases Mechanistic toxicology

Ranking compounds by gene expression profile comparisons Early predictive toxicology by comparison with Drug Toxicity signature databases

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CIT's services

CIT proposes a complete integrated toxicogenomics solution from in vivo studies to data mining, including:

• Assistance in customized toxicogenomics study design



• Adapted tissue sampling and DNA/RNA extraction procedures to ensure top level quality DNA/RNAs from more than 50 tissues from rodents and primates



• mRNA biomarker validation using real-time quantitative PCR (Applied Biosystems       7900 HT)



• Gene therapy products biodistribution evaluation



•  Whole transcriptome profiling on Affymetrix Genechip® arrays



• Complete data analysis



•  Easy understanding of compound safety and predictive toxicity by data comparison with toxicity signature databases.

These studies are conducted according to the highest quality standards.