CIT’s genetic toxicology department offers complete services in order to fulfil regulatory requirement or obtain screening data. Studies are designed according to international guidelines, including OECD, EC, OPPTS, ICH or Japanese guidelines.
In a dedicated building, the laboratory offers state-of-the-art and validated equipments, including specific validated software.
| In-vitro tests |
Bacterial reverse mutation, Ames test |
Salmonella typhimurium and, or Escherichia coli
Rat and/or hamster S9 (Prival & Mitchell method) |
| Mammalian cell gene mutation |
Mouse Lymphoma tk+/- cells |
| Mammalian chromosome aberration |
Human lymphocytes and, or L5178Y mouse lymphoma cells, by:
-
metaphase analysis,
or
- micronucleus test |
| In-vivo tests |
Micronucleus test
|
Bone marrow cells or peripheral blood cells of mice or rats |
| Chromosomal aberration |
Metaphase analysis on bone marrow cells of mice or rats |
The micronucleus test can be included in toxicology studies (28-day study for example).
|
| Choose a service description |
|
|
|
|
|
|
|
|
|
|
|
|
| |
|
Map
Short term, tolerance and in-vitro toxicology