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CIT’s ecotoxicology department offers complete services in order to fulfil regulatory requirement or obtain screening data. Studies are designed according to international guidelines, including OECD, EC, OPPTS, ICH or Japanese guidelines.
The laboratory is fully equipped to deal with “difficult” substances (e.g. volatile, poorly water-soluble or unstable) and radiolabelled substances.
A direct link with the Analytical Chemistry Department allows determination of solubility, stability, homogeneity and/or adsorption of the test substance under the experimental conditions. Regular sampling during the test and specifically designed equipment (e.g. GC, GC/MS, LC, LC/MS-MS) permit high precision analysis of the test substance to validate the study results.
STUDIES |
OECD |
EEC |
Acute Toxicity |
Fish |
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203 |
C 1 |
Daphnids |
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202 |
C 2 |
Algae |
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201 |
C 3 |
Bacteria |
Activated sludge, respiration inhibition test |
209 |
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Biodegradation |
Ready Biodegradability |
CO2 evolution test
Closed bottle test |
301 B
301 D |
C 4 - C
C 4 - E |
Inherent Biodegradability |
Zahn-Wellens / EMPA test |
302 B |
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Abiotic Degradation |
Hydrolysis |
Hydrolysis as a function
of pH |
111 |
C 7 |
Prolonged Toxicity |
Fish |
Early-life stage test
Embryo and sac-fry stages test
Juvenile growth test |
210
212
215 |
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Daphnids |
Reproduction test |
211 |
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Bioaccumulation |
Fish |
Sequential static test
Flow-through test |
305 A
305 E |
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Other aquatic studies can be performed on request.
A complete set of screening tests is also available for acute toxicity and biodegradation.
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Map
Short term, tolerance and in-vitro toxicology