In vitro toxicology tests
Corrosion/irritation
Skin corrosion on reconstructed human skin model EpiSkin (OECD 431)
Skin irritation on EpiSkin model with possible determination of interleukin 1α (OECD 439)
Bovine cornea opacity & permeability test - BCOP (OECD 437)
Ocular irritation on reconstructed human corneal epithelium
Skin sensitization
Peptide reactivity (DPRA)
MUSST assay in U937 cells
Phototoxicity
Photo 3T3 (OECD 432)
Photo EpiSkin
Cutaneous penetration
Human skin in dynamic Franz cells (OECD 428)
Immunotoxicology
Antibody-dependent cell cytotoxicity (ADCC)
Lymphocyte proliferation in multiple species
NK activity
Chemotaxis - neutrophil migration
Other assays currently under validation, check back soon.
Genetic toxicology tests
Screening tests
Mini-Ames test (2 to 5 strain combinations with and/or without S9 mix)
In vitro mini Micronucleus test
BlueScreen™
Regulatory tests
Ames test – bacterial mutagenesis (OECD 471)
Mouse lymphoma Assay (MLA) – in vitro mammalian mutagenesis (OECD 476)
Chromosome aberration test (OECD 473)
In Vitro Micronucleus test (OECD 487)
In Vivo Micronucleus test on mice or rats (OECD 474) with:
- cytogenetic microscope examination of bone marrow cells
- or flow cytometry analysis on erythrocytes.
The in vivo micronucleus test can be included in toxicity studies (4-week toxicity studies)
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